The study assessed medication adherence and quality of life of hypertensive patients attending State Specialist Hospital in Ikare Akoko, Ondo state. This study specifically assessed the quality of life of hypertensive patients; the level of medication adherence of hypertensive patients; and the predictability of medication adherence on quality of life of hypertensive patient attending State Specialist Hospital Ikare Akoko. This study adopted cross sectional descriptive survey design. The study population comprised of 202 hypertensive patients  in State Specialist Hospital in Ikare Akoko, Ondo State. The sample (148) for this study was derived by calculating sample from the total population using the Taro Yamane formula. Purposive sampling technique was used to select hypertensive patients attending NHIS clinic. An adapted questionnaire was used to collect data for the study. In ensuring the reliability of the instrument, 30 (10% of the sample size) hypertensive patients outside the study area were used. The overall reliability index was 0.798. The data collected were entered and analysed using SPSS version 27. Descriptive statistics was used to answer research questions, while linear regression analysis was used to test the hypothesis at 0.05 level of significance. The findings of the study revealed that most of the hypertensive patients had moderate medication adherence and quality of life. It is also revealed that medication adherence predicted quality of life of hypertensive patients. It was recommended among others that A community-based approach dedicated to enlightening both providers and patients should be implemented as it may contribute to improving the medication adherence among hypertensive patients.

Keywords: Medication Adherence, Quality of Life, Hypertensive Patients,

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